semaglutide vs tirzepatide efficacy weight loss SOUL trial shows oral has positive CV benefits in type 2 diabetes SELECT Trial

Adherence to Antihyperglycemic Medications and Glucagon-Like Peptide 1-Receptor Agonists in Type 2 Diabetes: Clinical Consequences and Strategies for Improvement

However, new research has found that up to one in 10 people may have genetic variants that make them resistant to the effects of these drugs

The study, which was published in the JCO Oncology Practice journal, looked at University of Pennsylvania Health System records from more than 111,000 women ages 45 to 80 over the last several years who were overweight or obese, to see who went on to develop breast cancer

In particular, since CB1Rs, the main target for the rewarding effects of cannabis, are expressed on incretin-secreting cells in rodents and may play a role in regulating GLP-1 secretion [58, 59]

Here are the key mechanisms: 1